Her sisters became queens in Portugal and France, Bohemia and Hungary, and Portugal, respectively.Īfter the early death of Isabella's father in September 1506, her mother's mental health began to deteriorate. Her brothers became the most powerful men in Europe as Holy Roman Emperors. Isabella and her siblings were considered the "noblest children" of her time. She had two older siblings, Eleanor and Charles, as well as three younger siblings Ferdinand, Mary and Catherine. She was baptized in Brussels by the Bishop of Cambrai, Henri de Berghes. Her father was the son of the reigning Holy Roman Emperor Maximilian I and his deceased consort Mary, Duchess of Burgundy, while her mother was the daughter of the Catholic Monarchs Ferdinand of Aragon and Isabella I of Castile. Isabella was born on 18 July 1501 in Brussels as the third child of Philip the Handsome, ruler of the Burgundian Netherlands and Joanna the Mad, heiress to the Spanish kingdoms of Castile and Aragon. She is pictured with her brother Charles and her sister Eleanor.
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